A 0.1–4 GHz software-defined radio (SDR) receiver with reconfigurable 10–100 MHz signal bandwidth is presented. The complete system design methodology, taking blocker effects into account, is provided. Fully differential Op-Amp with Miller feedback and feed-forward compensations is proposed to support wideband analog circuits with low power consumption. The stability and isolation of inverter-based trans-conductance amplifier are analyzed in details. The design approach of high linearity Tow-Thomas trans-impedance amplifier is presented to reject out-of-band blockers. To compensate for PVT variations, IIP2, frequency tuning, DC offset and IQ calibration are also integrated on-chip. The SDR receiver has been implemented in 65 nm CMOS, with 1.2/2.5 V power supply and a core chip area of 2.4 mm2. The receiver achieves S11 input matching below −10 dB and a NF of 3–8 dB across the 0.1–4 GHz range, and a maximum gain of 82–92 dB with a 70 dB dynamic range. Dissipated power spans from 30 to 90 mW across this entire frequency range. For LTE application with 20 MHz signal bandwidth and a LO frequency of 2.3 GHz, the receiver consumes 21 mA current.