By means of the “fibrinolysis autographs” described by Todd, the fibrinolytically active, histological structures were determined topographically in various dermatoses.
In the dermatoses investigated the already known fibrinolytic activity caused by a tissue activator of the veins, venules and capillaries, rarely of the arteries overrules with a focal lysis time of 10 to 15 min.
Lymph vessels, skin adnexes and inflammatory infiltrates always remain fibrinolytically inactive.
The lysis areas of the not-keratinized nucleated epithelial cells of the oral mucosa, which appeared after about two hours, demonstrate the lower fibrinolytic activity of epidermal origin.
An epidermal fibrinolytic activity also originates from spongiotic areas and excoriated regions of the acute and subacute eccema and parakeratotic cells of the transitional mucosa of the inner surface of the prepuce.
Parakeratotic scales exhibit a middle high fibrinolytic activity after 30 to 60 min, independent of the examined dermatoses.
The fibrinolytic activity of parakeratotic psoriatic scales appearing already after 15 to 30 min points out the special pathogenetical position of psoriasis vulgaris with excessively increased epidermopoesis.
Orthokeratotic scales have no tissue activator.
In none of the investigated dermatoses the focal lysis time is shortened. Dermatoses with inflammatory infiltrates in the corium tend to a prolongation of the focal lysis time and therewith to a decrease of the fibrinolytic activity.