In this work, some commercial and in-house nanoporous-based catalysts, such as USY, beta and mordenite zeolites, and mesoporous aluminosilicate molecular sieves such as MCM-48 and SBA-15, loaded with metals and acting as mono- and bimetallic bifunctional catalysts, were used for hydroisomerisation experiments in a fixed-bed reactor at pressures between 1 and 15 bar and at feed space time ranging from 2.57 to 10.26 h−1 (35.14–140.6 kg s mol−1) to hydroisomerise n-heptane over a temperature range of 210–270 °C. The effect of post-synthesis treatments of micro- and mesoporous catalysts was examined, regarding their activity, selectivity and stability, such as acid and steam dealumination techniques, acid leaching via a chelating agent, bimetal loading techniques, different platinum loading methods, and composite or hybrid catalyst generation. Results show that pore architecture is the most important factor affecting coke formation and deactivation in zeolite catalysts. It was found that those catalysts with high Si/Al ratios and those which had been acid-leached or steamed showed better activity, higher selectivity towards isomeric products and better time stability. Moreover, the balance between the number of metal sites and the number of acid sites played an important role in determining the activity, selectivity and stability of the bifunctional catalysts. Higher metal loading improves catalytic stability, due to a better balance and closeness of the catalytic functions. Moreover, the bimetallic catalyst improves the formation of smaller metal particles and better dispersion, which may affect selectivity and stability.